Questions, answered

PDRN (polydeoxyribonucleotide) is a mix of purified DNA fragments from salmon, one of the most talked-about actives in Korean dermatology. S‑DNA™ is Cotrini's PDRN, paired with calming Korean botanicals. It comes from salmon harvested for food, so none of the fish goes to waste.

In clinical testing, hydration rose 34% in 2 weeks and 52% in 4 weeks. Firmness and elasticity improved significantly by week 4, and every woman in the perception study said her skin felt softer.*

Yes. We haven’t seen any issues with either, and customers tell us it pairs especially well with retinol, which can be very drying. Apply your serum first, then the Night Cream. If you use a prescription retinoid, check with your dermatologist.

It's fragrance-free and was classified non-irritating in dermatologist-supervised patch testing. If your skin is reactive, patch-test on your inner arm first.

Yes. It’s designed for night, but you can also use it in the morning. Follow with sunscreen.

About 90 nights with nightly use, since a small amount goes a long way. That's under $3 a night. Unopened, a jar keeps for 2 years; once opened, use it within 6 months.

Cotrini is formulated in South Korea for our California-based company. It's fragrance-free.

We don’t recommend it. S‑DNA™ is derived from salmon, so if you have a fish allergy, please choose another product.

Please check with your healthcare provider before using it.

S‑DNA™ appears on the label as sodium DNA (polydeoxyribonucleotide), derived from salmon. Full ingredients: Aqua, PEG-8, Glycerin, PEG-90, Butyrospermum Parkii (Shea) Butter Extract, Ganoderma Lucidum Fruiting Body (Mushroom) Extract, Cnidium Officinale Rhizome Extract, Caprylyl Glycol, Cetearyl Alcohol, Glyceryl Stearate, PEG-100 Stearate, Polysorbate 60, Sorbitan Stearate, C13-14 Isoparaffin, Laureth-7, sodium DNA (polydeoxyribonucleotide), Betaine, Trehalose, Allantoin, Centella Asiatica Extract, Phellinus Linteus (Mushroom) Extract, Perilla Frutescens Leaf Extract, Scutellaria baicalensis root extract, Panax Ginseng Extract, Pueraria Lobata Root Extract, 1,2-Hexanediol, Butylene Glycol, Phenoxyethanol, Disodium EDTA (ethylenediaminetetraacetic acid).

Most people feel only a slight tingle as they press each patch on for 5–10 seconds, and that’s normal. The micro-darts dissolve as you sleep.

2–3 nights a week for three weeks, then take the fourth week off. At 2 nights a week, one box of 6 pairs lasts about a month.

Yes, and we recommend it. Put the patches on clean, dry skin first, then apply the Night Cream around them. Cream under the patches makes them slip overnight.

They’re designed for overnight. If you wear them during the day, keep them on for several hours so the micro-darts can dissolve.

No. Each pair is single use, since the micro-darts dissolve overnight.

Choose auto-replenish when you order and save 20% on every delivery. A new jar arrives every 3 months, timed to when your last one runs out. Skip or cancel anytime from your account.

It’s a 14-night supply of the Night Cream for $35, and your $35 is credited toward your first full jar.

The Night Cream and one box of the Micro‑Dart Eye Patches (6 pairs), for $329. Bought separately, they’re $378.99.

4 jars of the Night Cream and 12 boxes of the Eye Patches, shipped together, for $1,999. That’s less than a year of auto-replenish.

U.S. shipping is free on every order. Orders ship within 1⁠–⁠3 business days, with tracking. We ship across the U.S. and to Canada, the U.K. and parts of the EU. We can't ship to P.O. boxes.

You have 30 days. If you don't love it, email support@cotrini.com with your order number and return the jar, even empty, for a full product refund. Return shipping isn't covered, and refunds arrive 7⁠–⁠10 business days after we receive it. Orders from other retailers aren't eligible.

Yes. Email support@cotrini.com within 30 days with your order number for a full product refund.