The Micro‑Dart Eye Patches
Salmon DNA and EGF micro-darts for under-eyes, worn overnight. 6 pairs.
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Home / The Night Cream
Bestseller · Ageless Living 2026 Editor’s Pick
The Night Cream
Ultra Hydrating Night Cream with S‑DNA™, our salmon PDRN, and calming Korean botanicals.
5.0 on Google reviewsWake to visibly firmer, deeply hydrated skin.
- +52%skin hydration in 4 weeks, and every participant improved*
- 19%firmer skin, measured by instrument*
- 2 daysto a significant improvement in irritated skin’s moisture barrier, vs. untreated*
1.7 oz / 50 g · about 90 nights · under $3 a night
- Free U.S. shipping · ships in 1–3 business days
- Complimentary samples with every order
- 30-day money-back guarantee, even on an empty jar
New to Cotrini? Try the 14‑Night Discovery for $35, credited toward your first jar.Try 14 nights
What it does
A rich, cushioning night cream that deeply hydrates while you sleep. S‑DNA™ salmon PDRN works with calming Korean botanicals so skin looks firmer, smoother and more even by morning.
Ideal for dry or dehydrated skin, and for anyone who wants their skin to feel comforted overnight. Fragrance-free.
How to use
Every night, after cleansing. Scoop a small amount with the gold spatula, warm it between your fingertips and press it over your face and neck. Using the Eye Patches? Put them on first, then apply the cream around them.
Ingredients
Aqua, PEG-8, Glycerin, PEG-90, Butyrospermum Parkii (Shea) Butter Extract, Ganoderma Lucidum Fruiting Body (Mushroom) Extract, Cnidium Officinale Rhizome Extract, Caprylyl Glycol, Cetearyl Alcohol, Glyceryl Stearate, PEG-100 Stearate, Polysorbate 60, Sorbitan Stearate, C13-14 Isoparaffin, Laureth-7, sodium DNA (polydeoxyribonucleotide), Betaine, Trehalose, Allantoin, Centella Asiatica Extract, Phellinus Linteus (Mushroom) Extract, Perilla Frutescens Leaf Extract, Scutellaria baicalensis root extract, Panax Ginseng Extract, Pueraria Lobata Root Extract, 1,2-Hexanediol, Butylene Glycol, Phenoxyethanol, Disodium EDTA (ethylenediaminetetraacetic acid).
The proof
Clinically measured. Felt by the women who used it.
Tested independently on 34 women aged 30–55, against the untreated side of the face.
Measured by instrument
+52%Skin hydration in 4 weeks. Every participant improved
+34%Skin hydration in just 2 weeks
+23%Skin elasticity in 4 weeks
19%Firmer skin in 4 weeks
44%Showed visibly reduced fine lines in 4 weeks, graded by a dermatologist, vs. 3% on the untreated side
What women said
100%Agree skin feels firmer
100%Agree skin feels softer
91%Agree expression lines and wrinkles look reduced
97%Would use it again
0.05Irritation index in dermatologist patch testing: classified non-irritating
*Independent 4-week split-face study of 34 women aged 30–55, Delivery Clinical Studies (2023); perception study of 32 women over 4 weeks; anti-irritation study of 54 participants, skin irritated under lab conditions; 48-hour patch test of 22 participants. Individual results vary.
Real results
See the difference
44%of women showed visibly reduced wrinkles after 4 weeks, graded by a dermatologist, vs. 3% on the untreated side of the face.*
Before
After
Before
After
Before
After
Before
After*Independent 4-week split-face study, Delivery Clinical Studies S.A.S. (2023): 34 women aged 30–55; dermatologist evaluation of wrinkle reduction. Individual results vary.
Shop the Night CreamThe ritual
Three steps, every night.
- 01
Cleanse and dry
Pat your skin completely dry. Using the Eye Patches? Put them on now.
- 02
Warm it
Scoop a small amount with the gold spatula and warm it between your fingertips.
- 03
Press it in
Press over your face and neck, around the patches if you’re wearing them, and leave it on while you sleep.
What’s inside
Salmon DNA, with Korea’s calming botanicals.
Many brands now sell PDRN on its own. We pair it with a complex of Korean botanicals that comfort and protect the look of your skin barrier.
S‑DNA™ salmon PDRN
Purified DNA fragments from salmon, one of Korean dermatology’s most researched actives, for the look of renewed, resilient skin.
Reishi and Phellinus linteus
Two prized Korean mushrooms that help calm the look of stressed, tired skin.
Centella asiatica
A staple of Korean skincare that soothes and comforts dry, tight-feeling skin.
Ginseng and Scutellaria
Antioxidant-rich botanicals for a brighter, more even-looking complexion.
Shea butter, trehalose and betaine
Hold in moisture so skin feels soft and cushioned by morning.
Allantoin
Softens and soothes. And the formula is fragrance-free.
Full ingredient list
Aqua, PEG-8, Glycerin, PEG-90, Butyrospermum Parkii (Shea) Butter Extract, Ganoderma Lucidum Fruiting Body (Mushroom) Extract, Cnidium Officinale Rhizome Extract, Caprylyl Glycol, Cetearyl Alcohol, Glyceryl Stearate, PEG-100 Stearate, Polysorbate 60, Sorbitan Stearate, C13-14 Isoparaffin, Laureth-7, sodium DNA (polydeoxyribonucleotide), Betaine, Trehalose, Allantoin, Centella Asiatica Extract, Phellinus Linteus (Mushroom) Extract, Perilla Frutescens Leaf Extract, Scutellaria baicalensis root extract, Panax Ginseng Extract, Pueraria Lobata Root Extract, 1,2-Hexanediol, Butylene Glycol, Phenoxyethanol, Disodium EDTA (ethylenediaminetetraacetic acid).
In their words
“If you’ve been searching for the face cream of your dreams, you can stop looking and buy Cotrini. It has helped my skin with moisturizing and firming. I feel like I look younger and brighter!”
“From the very first use, my skin felt noticeably softer, smoother, and deeply hydrated. With continued use, I’ve seen real improvements in my skin’s texture and overall glow.”
“I started using this cream about 3 years ago… I’ve used $600 creams and saw no difference in my skin, but for a fraction of the cost Cotrini is a much better option.”
“I love the results I see in the morning… The product lasts a long time so it’s definitely worth the purchase. I think I’m on my 4th order now.”
“I’ve been using Cotrini Cream day and night for over 3 years, and I just turned 50 — my skin has honestly never felt this hydrated, bouncy, and healthy.”
“Hands down the best face cream and client service I’ve ever experienced. If I could give 10 stars I would, it’s that good.”
“Omg this product is amazing! I was introduced to it at a retreat and I cannot stop telling people about it.”
“After applying it for a couple of nights I could tell a difference in my skin. It keeps my skin so moisturized and looking amazing.”
“It’s been difficult to find a night cream that works for me where I see VISIBLE results. Cotrini is fabulous!”
“My skin looks and feels amazing in a short time. I finally found the night cream I’ve been searching for to help with my fine lines.”
“I have super dry skin and live in a dry climate, and this makes me feel like I’m in a spa. FR I feel like it’s an investment in myself.”
“Cotrini is truly the best skincare product I’ve ever used. The texture is so rich in application, but after absorbing, feels light and fresh.”
“This ultra hydrating night cream is the best I have used in a LONG time! … In just a little under a week I could tell my skin was changing.”
“My fine lines and wrinkles look tighter and smoother, and my entire complexion feels so much more even and refreshed.”
Excerpts from reviews on Cotrini Skincare’s Google Business Profile. Read all 19 on Google
Never run out. Save 20%.
- A new jar every 3 months
- Timed to when your last one runs out
- Skip or cancel anytime
Questions
When will I see results?
In clinical testing, hydration rose 34% in 2 weeks and 52% in 4 weeks. Firmness and elasticity improved significantly by week 4, and every woman in the perception study said her skin felt softer.*
Can I use it with retinol or vitamin C?
Yes. We haven’t seen any issues with either, and customers tell us it pairs especially well with retinol, which can be very drying. Apply your serum first, then the Night Cream. If you use a prescription retinoid, check with your dermatologist.
Is it gentle enough for reactive skin?
It’s fragrance-free and was classified non-irritating in dermatologist-supervised patch testing. If your skin is reactive, patch-test on your inner arm first.
Can I use it during the day?
Yes. It’s designed for night, but you can also use it in the morning. Follow with sunscreen.
How long does a jar last?
About 90 nights with nightly use, since a small amount goes a long way. That’s under $3 a night. Unopened, a jar keeps for 2 years; once opened, use it within 6 months.
How does auto-replenish work?
Choose auto-replenish above and save 20% on every jar. A new one arrives every 3 months, timed to when your last one runs out. Skip or cancel anytime from your account.
Can I use it if I have a fish allergy?
We don’t recommend it. S‑DNA™ is derived from salmon, so if you have a fish allergy, please choose another product.
Can I use it while pregnant or breastfeeding?
Please check with your healthcare provider before using it.
What if it isn’t right for me?
You have 30 days. If you don’t love it, email support@cotrini.com with your order number and return the jar, even empty, for a full product refund. Return shipping isn’t covered, and refunds arrive 7–10 business days after we receive it.